Near Death Experiences
and the Dorsal Attention network (DAT) of the brain may be a defining feature of consciousness.
Four-year 1.4M grant award by NIH/NIGMS to PI Dr. Tony Hudetz to continue studying the neural mechanism by which general anesthetics modulate consciousness.
The overall goal of this research project is to investigate local neuronal mechanisms in the cerebral cortex associated with complex, natural sensory experience and to determine how general anesthetics may alter sensory-specific contents of consciousness. Our general hypothesis is that anesthetic modulation of consciousness is closely tied to the modification of specific spatiotemporal patterns of neuronal activity in local cortical circuits. We will test our hypothesis in the rat visual and association cortex as a model system in vivo.
Drs. George Mashour and Dinesh Pal were recently awarded an NIH R01 to study the role of the prefrontal cortex in arousal states
These studies will yield fundamental mechanistic knowledge of the neural pathways involved in arousal and recovery of consciousness, and will be of translational relevance across numerous fields.
Dr. Kamran Diba was awarded a multi-PI R01 grant, with co-PI Dr. Edwin (Ted) Abel at the University of Iowa, from NIMH.
This is a collaborative effort to investigate the “Molecular, cellular and circuit effects of sleep deprivation on hippocampal function” from multiple angles. A key part of this project will involve measurements and analyses in Dr. Diba’s lab of large-scale neuronal firing patterns in the hippocampus during memory acquisition and consolidation in waking and sleep, in rested and sleep-deprived animals. Dr. Kamran Diba was also awarded an R21 grant from the NIMH. In this work, Dr. Diba’s lab will use chemogenetic tools to manipulate cAMP protein signaling in hippocampal neurons in-vivo, in order to evaluate effects on hippocampal oscillations and memory.
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Mawla, I et al, “Greater somatosensory afference with acupuncture increases primary somatosensory connectivity and alleviates fibromyalgia pain via insular GABA: A randomized neuroimaging trial". Arthritis Rheumatol 2020
Lee, H et al, “Differential effect of anesthesia on visual cortex neurons with diverse population coupling". Neuroscience 2020
Larkin, T et al, “Altered network architecture of functional brain communities in chronic nociplastic pain". Neuroimage 2020
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Zilio, F et al, “Are intrinsic neuronal timescales related to sensory processing? Evidence from abnormal behavioral states". Neuroimage 2020
Lee, H et al, “State-Dependent Cortical Unit Activity Reflects Dynamic Brain State Transitions in Anesthesia". J Neurosci 2020
Vlisides, P et al, “Deep Anaesthesia". Lancet 2020
Kallionpää, R et al, “Alpha band frontal connectivity is a state-specific electroencephalographic correlate of unresponsiveness during exposure to dexmedetomidine and propofol". Br J Anaesth 2020
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NEUROSCI 704 – Course Description: The nature and the neural basis of consciousness is a foundational question in neuroscience. As a scientific inquiry, it speaks to the existence of reality as we perceive it, and from a translational and therapeutic perspective, a fundamental understanding of the biological basis of consciousness has implications for disorders ranging from psychiatric disorders to the disorders of consciousness. In this course, we will start with a brief overview of the current neuroscientific frameworks and theories to study consciousness, and then as we move forward, will discuss the recent literature on the neurobiology of physiological (sleep), pharmacological (anesthesia, psychedelic states), and pathological states (coma, vegetative state) of consciousness. The students will participate in discussion and presentation of recent relevant literature.
Contacts: Dinesh Pal and Giancarlo Vanini
This lecture has been postponed. Professor Beverley A. Orser from the University of Toronto will deliver the 5th annual Domino Lecture sponsored by CCS.
To view this day-long symposium with national and international experts, please see: https://www.youtube.com/watch?v=WZcF75RtnvQ&feature=youtu.be