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CCS will host the 3rd CCS Symposium at the University of Michigan(Thursday, August 9, in the 4th floor Rackham Amphitheatre). This year’s symposium will focus on the topic of Consciousness and Pain. We have an exciting program that includes institutional, national, and international speakers.

The CCS will sponsor another Neuroscience Graduate Program course on the Cognitive Neuroscience of Consciousness in the Fall of 2018. Please encourage your students, fellows, or faculty to contact me if they are interested. All learners are welcomed for these dynamic discussions!

Do explosive brain networks explain hypersensitivity in chronic pain? A new collaboration between the CCS and Chronic Pain and Fatigue Research Center (http://www.med.umich.edu/painresearch/) applied novel network science to understand the subjective experience of pain. For more information see: https://labblog.uofmhealth.org/lab-report/does-an-exploding-brain-network-cause-chronic-pain

Research

Congratulation to Michael Brito (a second-year PhD candidate in Neuroscience working under Drs. George Mashour and Dinesh Pal) who has been awarded National Science Foundation graduate research fellowship to study consciousness at the CCS for his doctoral dissertation.

2017- Dr. Dinesh Pal, CCS faculty and Assistant Professor of Anesthesiology, has been awarded a new R01 from the National Institutes of Health to study the mechanistic underpinnings of the interactions between sleep homeostasis and sedation

Dr. Pal will employ sophisticated techniques including high-density EEG in rodents and multi-neuroanalyte monitoring using mass spectrometry to answer a fundamental question: if and how sedatives can provide a sleep-like state. CCS director, Dr. Mashour is a co-investigator on the grant.

2017- CCS faculty receive new NIH funding to study the role of the hypothalamus in level of consciousness

Dr. Giancarlo Vanini will work with his co-PI, George Mashour, and other faculty in the Center for Consciousness Science to understand how sleep-promoting regions in the hypothalamus regulate the entry into and exit from the anesthetized state. Using cutting-edge chemogenetic techniques, they will also explore how these subcortical nuclei alter cortical connectivity and dynamics.

2016- CCS work on mechanisms of anesthetic-induced unconsciousness recognized by major journals of anesthesiology

Theoretical and empirical work of CCS members has been published and featured in the journals Anesthesiology and Anesthesia & Analgesia. Experimental work on the neural correlates of consciousness was recognized with the cover articles for the November issue of Anesthesiology. Furthermore, the “infographic” sections of both journals featured the work on frontal-parietal network disruptions identified by the CCS during propfol-, sevoflurane-, and ketamine-induced unconsciousness. See:http://anesthesiology.pubs.asahq.org/data/Journals/JASA/935792/5FF01.png and http://journals.lww.com/anesthesia-analgesia/Fulltext/2016/11000/Towards_Understanding_Mechanisms_of_Anesthesia.1.aspx

 

2016- CCS faculty receive NIH grant to study cortical connectivity in computational models, non-human primates, and surgical patients

CCS Directors Mashour and Lee have just been awarded a NIH R01 to conduct computational, neurobiological, and clinical studies of consciousness and anesthesia. CCS faculty Cindy Chestek (biomedical engineering) and Parag Patil (neurosurgery) are co-investigators.

 

2015- CCS faculty Dr. Cindy Chestek receives NIH grant through the BRAIN initiative to advance neuronal recording

Dr. Chestek (primary faculty in Biomedical Engineering) and her colleague Joshua Berke in Psychology have been awarded a BRAIN initiative grant in the amount of $2.6 million to develop a high density electrode array of carbon threads thinner than human hair for recording from over a thousand neurons at the same time. These tools could help map out the circuitry of the brain and see how individual neurons communicate with one another. Dr. Chestek is the recipient of a CCS pilot grant on this subject.

2015- CCS develops new collaborations with consciousness research groups at the Technische Universität Munich (TUM) in Germany and the University of Turku in Finland

CCS director George Mashour recently served as an August-Wilhelm Scheer Visiting Professor at TUM and an honorary fellow of the TUM Institute for Advanced Study. He and CCS directors UnCheol Lee and Tony Hudetz are collaborating on projects related to consciousness, anesthesia and coma with the multidisciplinary research team of Dr. Eberhard Kochs. CCS is also working collaboratively on projects related to consciousness and anesthesia with the research groups of Dr. Harry Scheinin and Dr. Annti Revonsuo in Turku, Finland.

2015- CCS receives grants from the National Institutes of Health and the James S. McDonnell Foundation to study brain networks as consciousness is lost and reconstituted

Dr. George Mashour and the CCS have been awarded major grants from the NIH and the prestigious James S. McDonnell Foundation to study consciousness in humans and nonhuman primates. The new NIH RO1 will fund studies of healthy volunteers receiving ketamine and nitrous oxide; parallel studies examining cortical information transfer in the monkey brain during anesthetic state transitions will also be conducted. The McDonnell Foundation grant funds a translational neuroscience project conducted across multiple U.S. and Australian centers, led by the Center for Consciousness Science at the University of Michigan. The goal of this project is to study how the brain reconstitutes consciousness and cognition after major perturbations such as general anesthesia or seizures. The multidisciplinary teams assembled for the studies span the fields of neuroscience, physics, computational science, biomedical engineering, pain neurobiology, anesthesiology, neurosurgery, and psychiatry.

Recent publications by CCS faculty

Education

Professor Emery Brown from Harvard and MIT gave the 3rd annual Edward F. Domino Lecture sponsored by CCS (Thursday, March 22, 2018).

CCS Director George Mashour delivers the 6th Annual Thomas Willis Lecture in Clinical Neuroscience at the University of Oxford on the subject of consciousness and anesthesia.

More than 10 CCS faculty, fellows, and graduate students presented at the international Science of Consciousness Conference in Tucson from April 2-7, which was co-sponsored by CCS.