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Current News

  • New CCS study published in Current Biology by Dr. Pal and colleagues reveals role of prefrontal cortex in level of consciousness.

  • CCS hosted the 3rd CCS Symposium at the University of Michigan This year’s symposium focused on the topic of Consciousness and Pain, with an exciting program that included institutional, national, and international speakers.
  • CCS sponsors annual Neuroscience Graduate Program course on the Cognitive Neuroscience of Consciousness in the Fall of 2018. Please encourage your students, fellows, or faculty to contact gmashour@umich.edu if they are interested. All learners are welcomed for these dynamic discussions!

Research

2018 – Dr. Kamran Diba was awarded a multi-PI R01 grant, with co-PI Dr. Edwin (Ted) Abel at the University of Iowa, from NIMH.
This is a collaborative effort to investigate the “Molecular, cellular and circuit effects of sleep deprivation on hippocampal function” from multiple angles. A key part of this project will involve measurements and analyses in Dr. Diba’s lab of large-scale neuronal firing patterns in the hippocampus during memory acquisition and consolidation in waking and sleep, in rested and sleep-deprived animals. Dr. Kamran Diba was also awarded an R21 grant from the NIMH. In this work, Dr. Diba’s lab will use chemogenetic tools to manipulate cAMP protein signaling in hippocampal neurons in-vivo, in order to evaluate effects on hippocampal oscillations and memory.

2018- Dr. Anthony G. Hudetz, was awarded an R01 grant by the National Institute of General Medical Science of NIH to study the system-level neural mechanisms of anesthetic-induced unconsciousness.
Dr. Hudetz and his team will use functional magnetic resonance imaging to test the hypothesis that healthy human participants may be able to willfully engage in task-related mental imagery when sedated to the point of behavioral unresponsiveness and will seek to find a causal link between the state of intrinsic brain activity and volitional mental activity. The project will advance our understanding of the neuronal mechanisms of anesthesia with significant translational and paradigmatic impact for the clinical assessment of the state of consciousness and for the potential communication of patients via volitional mental activity.

 

2018- Dr. Phillip Vlisides, a core CCS faculty, was awarded an NIH Career Development Grant (K23) to study consciousness and cognition after surgery.
Dr. Vlisides and his team will analyze advanced neurophysiologic patterns-using electroencephalography and near-infrared spectroscopy-to better understand and predict cognitive impairment after surgery.

 

2018- Congratulations to Michael Brito (a second-year PhD candidate in Neuroscience working under Drs. George Mashour and Dinesh Pal) who has been awarded an National Science Foundation graduate research fellowship to study consciousness for his doctoral dissertation

2017- Dr. Dinesh Pal, CCS faculty and Assistant Professor of Anesthesiology, has been awarded a new R01 from the National Institutes of Health to study the mechanistic underpinnings of the interactions between sleep homeostasis and sedation

Dr. Pal will employ sophisticated techniques including high-density EEG in rodents and multi-neuroanalyte monitoring using mass spectrometry to answer a fundamental question: if and how sedatives can provide a sleep-like state. CCS director, Dr. Mashour is a co-investigator on the grant.


2017- CCS faculty receive new NIH funding to study the role of the hypothalamus in level of consciousness
Dr. Giancarlo Vanini will work with his co-PI, George Mashour, and other faculty in the Center for Consciousness Science to understand how sleep-promoting regions in the hypothalamus regulate the entry into and exit from the anesthetized state. Using cutting-edge chemogenetic techniques, they will also explore how these subcortical nuclei alter cortical connectivity and dynamics.

2016- CCS faculty receive NIH grant to study cortical connectivity in computational models, non-human primates, and surgical patients

CCS Directors Mashour and Lee have just been awarded a NIH R01 to conduct computational, neurobiological, and clinical studies of consciousness and anesthesia. CCS faculty Cindy Chestek (biomedical engineering) and Parag Patil (neurosurgery) are co-investigators.

2015- CCS receives grants from the National Institutes of Health and the James S. McDonnell Foundation to study brain networks as consciousness is lost and reconstituted
Dr. George Mashour and the CCS have been awarded major grants from the NIH and the prestigious James S. McDonnell Foundation to study consciousness in humans and nonhuman primates. The new NIH R01 will fund studies of healthy volunteers receiving ketamine and nitrous oxide; parallel studies examining cortical information transfer in the monkey brain during anesthetic state transitions will also be conducted. The McDonnell Foundation grant funds a translational neuroscience project conducted across multiple U.S. and Australian centers, led by the Center for Consciousness Science at the University of Michigan. The goal of this project is to study how the brain reconstitutes consciousness and cognition after major perturbations such as general anesthesia or seizures. The multidisciplinary teams assembled for the studies span the fields of neuroscience, physics, computational science, biomedical engineering, pain neurobiology, anesthesiology, neurosurgery, and psychiatry.

 

Recent publications by CCS faculty

Huang et al, Brain imaging reveals covert consciousness during behavioral unresponsiveness induced by propofol, Sci Rep 2018

Kim et al, Mechanisms of hysteresis in human brain networks during transitions of consciousness and unconsciousness: Theoretical principles and empirical evidence, PLOS Comp BIol. 2018

Blain-Moraes S et al., Consciousness and Personhood in Medical Care. Front Hum Neurosci. 2018

Mashour GA, Highways of the Brain, Traffic of the Mind. Anesthesiology 2018

Thiery T et al., Long-range temporal correlations in the brain distinguish conscious wakefulness from induced unconsciousness.
Neuroimage 2018

Lee H et al, Topographic reconfiguration of local and shared information in anesthetic-induced unconsciousness, Entropy 2018

Vlisides PE et al, Subanaesthetic ketamine and altered states of consciousness in humans, Br J Anaesth 2018

Lee U et al, The stochastic nature of neural inertia, Br J Anaesth 2018

Huang et al, Disrupted neural variability during propofol-induced sedation and unconsciousness. Hum Brain Mapp 2018

Pal D et al, Differential role of prefrontal and parietal cortices in controlling level of consciousness. Curr Biol 201

Mashour GA, The controversial correlates of consciousness. Science 2018

Lee U et al, Role of network science in the study of anesthetic state transitions. Anesthesiology 2018

Scheinin A et al, Differentiating Drug-related and State-related Effects of Dexmedetomidine and Propofol on the Electroencephalogram. Anesthesiology 2018

Liu X et al, Regional entropy of functional imaging signals varies differently in sensory and cognitive systems during propofol-modulated loss and return of behavioral responsiveness. Brain Imaging Behav 2018

Mashour GA et al, Systems Neuroscience: The Exciting Journey to Oblivion. Curr Biol 2018

Mashour GA et al, Neural correlates of unconsciousness in large-scale brain networks. Trends Neurosci 2018

Kim H et al, Estimating the integrated information measure phi from high-density electroencephalography during states of consciousness in humans. Front Hum Neurosci 2018

Huang Z et al, Timescales of intrinsic BOLD signal dynamics and functional connectivity in pharmacologic and neuropathologic states of unconsciousness. J Neurosci 2018

Lee U, Kim M, Lee K, Kaplan CM, Clauw DJ, Kim S, Mashour GA, Harris RE, Functional Brain Network Mechanism of Hypersensitivity in Chronic Pain. Sci Rep 2018

Palanca BJA, Avidan MS, Mashour GA, Human neural correlates of sevoflurane-induced unconsciousness. Br J Anaesth 2017

Vanini G, Nucleus Accumbens: A Novel Forebrain Mechanism Underlying the Increase in Pain Sensitivity Caused by Rapid Eye Movement (REM) Sleep Deprivation. Pain 2017

Maurer AP, Burke SN, Diba K, Barnes CA, Attenuated Activity across Multiple Cell Types and Reduced Monosynaptic Connectivity in the Aged Perirhinal Cortex. J Neurosci 2017

Hambrecht-Wiedbusch VS, Gabel M, Liu LJ, Imperial JP, Colmenero AV, Vanini G, Preemptive Caffeine Administration Blocks the Increase in Postoperative Pain Caused by Previous Sleep Loss in the Rat: A Potential Role for Preoptic Adenosine A2A Receptors in Sleep-Pain Interactions. Sleep 2017

Kim et al, Relationship of Topology, MultiscalePhase Synchronization, and StateTransitions in Human Brain Networks. Front Comp Neurosci 2017

Blain-Moraes et al, Network Efficiency and Posterior Alpha Patterns Are Markers of Recovery from General Anesthesia: A High-Density Electroencephalography Study in Healthy Volunteers. Front Hum Neurosci 2017

Mashour et al, Bottom-Up and Top-Down Mechanisms of General Anesthetics Modulate Different Dimensions of Consciousness. Front Neural Circuits 2017

Pal et al, Propofol, Sevoflurane, and Ketamine Induce a Reversible Increase in Delta-Gamma and Theta-Gamma Phase-Amplitude Coupling in Frontal Cortex of Rat. Front Syst Neuroscience 2017

Maier et al, Protocol for the Reconstructing Consciousness and Cognition (ReCCognition) Study. Front Hum Neuroscience 2017

Liu X et al, Fine-grained parcellation of brain connectivity improves differentiation of states of consciousness during graded propofol sedation. Brain Connect 2017

Vlisides PE et al, Neuropohysiologic correlates of ketamine sedation and anesthesia : A high density electroencephalography study in healthy volunteers, Anesthesiology 2017

Moon J-Y et al, Structure shapes dynamics and directionality in diverse brain networks: mathematical principles and empirical confirmation in three species, Sci Rep 2017

Li D et al, Accelerated recovery of consciousness after general anesthesia is associated with increased functional brain connectivity in the human gamma bandwidth, Front Syst Neurosci 2017

Hambrecht-Wiedbusch VS et al, Administration of subanesthetic ketamine during isoflurane anesthesia induces burst suppression but accelerates recovery. Anesthesiology 2017

Education

  • 2018- Professor Emery Brown from Harvard and MIT delivers the 3rd annual Edward F. Domino Lecture sponsored by CCS.

  • CCS Director George Mashour delivers the 2018 Thomas Willis Lecture in Clinical Neuroscience at the University of Oxford on the subject of consciousness and anesthesia.

  • More than 10 CCS faculty, fellows, and graduate students presented at the international 2018 Science of Consciousness Conference in Tucson, which was co-sponsored by CCS.