CCS Symposium 2020Slide Center for Consciousness Science Symposium

Near Death Experiences

Date: TBD

Zirui Slide Dr. Zirui Huang's study suggests that the shifting balance between the Default Mode Network (DMN)

and the Dorsal Attention network (DAT) of the brain may be a defining feature of consciousness.
Sean Slide Disrupted Global Brain Signaling
During Unconsciousness
New fMRI study by Tanabe et al. published in the March 2020 issue of the journal Anesthesiology suggests that the global temporal coordination of neuronal activity across the entire brain is a unitary indicator of various states of consciousness including sleep, general anesthesia, and unresponsive wakefulness syndrome, whereas the relationship of the global and local brain activity defines the particular quality of each unconscious state. Click Here for Video Click Here for Article
UnCheol paper  Slide Neural Correlates of Shamanic State of Consciousness

CCS faculty publish article on
Current News
Dinesh Pal, PhD

Dinesh Pal, Ph.D., receives New Investigator Award from American Physiological Society

CCS researcher Dinesh Pal, Ph.D., Assistant Professor of Anesthesiology and Department of Molecular & Integrative Physiology has received the American...
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Asymmetric Neural Dynamics article published in Neuroimage by CCS Faculty

Anesthetics are known to disrupt neural interactions in cortical and subcortical brain circuits. While the effect of anesthetic drugs on...
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CCS faculty publish article on neural correlates of shamanic state of consciousness

Shamanic trance is an altered state of consciousness used by shamanic practitioners to glean information to be used for the...
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Research

Four-year 1.4M grant award by NIH/NIGMS to PI Dr. Tony Hudetz to continue studying the neural mechanism by which general anesthetics modulate consciousness.

The overall goal of this research project is to investigate local neuronal mechanisms in the cerebral cortex associated with complex, natural sensory experience and to determine how general anesthetics may alter sensory-specific contents of consciousness. Our general hypothesis is that anesthetic modulation of consciousness is closely tied to the modification of specific spatiotemporal patterns of neuronal activity in local cortical circuits. We will test our hypothesis in the rat visual and association cortex as a model system in vivo.

Drs. George Mashour and Dinesh Pal were recently awarded an NIH R01 to study the role of the prefrontal cortex in arousal states

These studies will yield fundamental mechanistic knowledge of the neural pathways involved in arousal and recovery of consciousness, and will be of translational relevance across numerous fields.

Dr. Kamran Diba was awarded a multi-PI R01 grant, with co-PI Dr. Edwin (Ted) Abel at the University of Iowa, from NIMH.

This is a collaborative effort to investigate the “Molecular, cellular and circuit effects of sleep deprivation on hippocampal function” from multiple angles. A key part of this project will involve measurements and analyses in Dr. Diba’s lab of large-scale neuronal firing patterns in the hippocampus during memory acquisition and consolidation in waking and sleep, in rested and sleep-deprived animals. Dr. Kamran Diba was also awarded an R21 grant from the NIMH. In this work, Dr. Diba’s lab will use chemogenetic tools to manipulate cAMP protein signaling in hippocampal neurons in-vivo, in order to evaluate effects on hippocampal oscillations and memory.

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Recent publications by CCS faculty
Huang, Z et al, “Asymmetric neural dynamics characterize loss and recovery of consciousness". Neuroimage 2021
Huels, E et al, “Neural Correlates of the Shamanic State of Consciousness". Front Neurosci 2021
Parkar, A et al, “Carbachol and nicotine in prefrontal cortex have differential effects on sleep-wake states". Front Neurosci 2020
Mawla, I et al, “Greater somatosensory afference with acupuncture increases primary somatosensory connectivity and alleviates fibromyalgia pain via insular GABA: A randomized neuroimaging trial". Arthritis Rheumatol 2020
Lee, H et al, “Differential effect of anesthesia on visual cortex neurons with diverse population coupling". Neuroscience 2020
Larkin, T et al, “Altered network architecture of functional brain communities in chronic nociplastic pain". Neuroimage 2020
Mahdid, Y et al, “Assessing the quality of wearable EEG systems using functional connectivity". IEEE Access 2020
Zilio, F et al, “Are intrinsic neuronal timescales related to sensory processing? Evidence from abnormal behavioral states". Neuroimage 2020
Lee, H et al, “State-Dependent Cortical Unit Activity Reflects Dynamic Brain State Transitions in Anesthesia". J Neurosci 2020
Vlisides, P et al, “Deep Anaesthesia". Lancet 2020
Kallionpää, R et al, “Alpha band frontal connectivity is a state-specific electroencephalographic correlate of unresponsiveness during exposure to dexmedetomidine and propofol". Br J Anaesth 2020
Brito, M et al, "State-Dependent and Bandwidth-Specific Effects of Ketamine and Propofol on Electroencephalographic Complexity in Rats". Front Syst Neurosci 2020
Education

Neuroscience of Consciousness Course Fall 2021

NEUROSCI 704 – Course Description: The nature and the neural basis of consciousness is a foundational question in neuroscience. As a scientific inquiry, it speaks to the existence of reality as we perceive it, and from a translational and therapeutic perspective, a fundamental understanding of the biological basis of consciousness has implications for disorders ranging from psychiatric disorders to the disorders of consciousness. In this course, we will start with a brief overview of the current neuroscientific frameworks and theories to study consciousness, and then as we move forward, will discuss the recent literature on the neurobiology of physiological (sleep), pharmacological (anesthesia, psychedelic states), and pathological states (coma, vegetative state) of consciousness. The students will participate in discussion and presentation of recent relevant literature.

Contacts: Dinesh Pal and Giancarlo Vanini

Edward F. Domino Lecture in Consciousness Science

This lecture has been postponed. Professor Beverley A. Orser from the University of Toronto will deliver the 5th annual Domino Lecture sponsored by CCS.

Hundreds attend CCS symposium on psychedelic neuroscience and therapy

To view this day-long symposium with national and international experts, please see: https://www.youtube.com/watch?v=WZcF75RtnvQ&feature=youtu.be

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