2018- Dr. Phillip Vlisides, a core CCS faculty, was awarded an NIH Career Development Grant (K23) to study consciousness and cognition after surgery.
Dr. Vlisides and his team will analyze advanced neurophysiologic patterns-using electroencephalography and near-infrared spectroscopy-to better understand and predict cognitive impairment after surgery.
2018- Congratulations to Michael Brito (a second-year PhD candidate in Neuroscience working under Drs. George Mashour and Dinesh Pal) who has been awarded an National Science Foundation graduate research fellowship to study consciousness for his doctoral dissertation
2017- Dr. Dinesh Pal, CCS faculty and Assistant Professor of Anesthesiology, has been awarded a new R01 from the National Institutes of Health to study the mechanistic underpinnings of the interactions between sleep homeostasis and sedation
Dr. Pal will employ sophisticated techniques including high-density EEG in rodents and multi-neuroanalyte monitoring using mass spectrometry to answer a fundamental question: if and how sedatives can provide a sleep-like state. CCS director, Dr. Mashour is a co-investigator on the grant.
2017- CCS faculty receive new NIH funding to study the role of the hypothalamus in level of consciousness
Dr. Giancarlo Vanini will work with his co-PI, George Mashour, and other faculty in the Center for Consciousness Science to understand how sleep-promoting regions in the hypothalamus regulate the entry into and exit from the anesthetized state. Using cutting-edge chemogenetic techniques, they will also explore how these subcortical nuclei alter cortical connectivity and dynamics.
2016- CCS faculty receive NIH grant to study cortical connectivity in computational models, non-human primates, and surgical patients
CCS Directors Mashour and Lee have just been awarded a NIH R01 to conduct computational, neurobiological, and clinical studies of consciousness and anesthesia. CCS faculty Cindy Chestek (biomedical engineering) and Parag Patil (neurosurgery) are co-investigators.
2015- CCS receives grants from the National Institutes of Health and the James S. McDonnell Foundation to study brain networks as consciousness is lost and reconstituted
Dr. George Mashour and the CCS have been awarded major grants from the NIH and the prestigious James S. McDonnell Foundation to study consciousness in humans and nonhuman primates. The new NIH R01 will fund studies of healthy volunteers receiving ketamine and nitrous oxide; parallel studies examining cortical information transfer in the monkey brain during anesthetic state transitions will also be conducted. The McDonnell Foundation grant funds a translational neuroscience project conducted across multiple U.S. and Australian centers, led by the Center for Consciousness Science at the University of Michigan. The goal of this project is to study how the brain reconstitutes consciousness and cognition after major perturbations such as general anesthesia or seizures. The multidisciplinary teams assembled for the studies span the fields of neuroscience, physics, computational science, biomedical engineering, pain neurobiology, anesthesiology, neurosurgery, and psychiatry.
Recent publications by CCS faculty
Huang et al, Disrupted neural variability during propofol-induced sedation and unconsciousness. Hum Brain Mapp 2018
Pal D et al, Differential role of prefrontal and parietal cortices in controlling level of consciousness. Curr Biol 201
Mashour GA, The controversial correlates of consciousness. Science 2018
Lee U et al, Role of network science in the study of anesthetic state transitions. Anesthesiology 2018
Scheinin A et al, Differentiating Drug-related and State-related Effects of Dexmedetomidine and Propofol on the Electroencephalogram. Anesthesiology 2018
Liu X et al, Regional entropy of functional imaging signals varies differently in sensory and cognitive systems during propofol-modulated loss and return of behavioral responsiveness. Brain Imaging Behav 2018
Mashour GA et al, Systems Neuroscience: The Exciting Journey to Oblivion. Curr Biol 2018
Mashour GA et al, Neural correlates of unconsciousness in large-scale brain networks. Trends Neurosci 2018
Kim H et al, Estimating the integrated information measure phi from high-density electroencephalography during states of consciousness in humans. Front Hum Neurosci 2018
Lee U, Kim M, Lee K, Kaplan CM, Clauw DJ, Kim S, Mashour GA, Harris RE, Functional Brain Network Mechanism of Hypersensitivity in Chronic Pain. Sci Rep 2018
Palanca BJA, Avidan MS, Mashour GA, Human neural correlates of sevoflurane-induced unconsciousness. Br J Anaesth 2017
Maurer AP, Burke SN, Diba K, Barnes CA, Attenuated Activity across Multiple Cell Types and Reduced Monosynaptic Connectivity in the Aged Perirhinal Cortex. J Neurosci 2017
Hambrecht-Wiedbusch VS, Gabel M, Liu LJ, Imperial JP, Colmenero AV, Vanini G, Preemptive Caffeine Administration Blocks the Increase in Postoperative Pain Caused by Previous Sleep Loss in the Rat: A Potential Role for Preoptic Adenosine A2A Receptors in Sleep-Pain Interactions. Sleep 2017
Kim et al, Relationship of Topology, MultiscalePhase Synchronization, and StateTransitions in Human Brain Networks. Front Comp Neurosci 2017
Blain-Moraes et al, Network Efficiency and Posterior Alpha Patterns Are Markers of Recovery from General Anesthesia: A High-Density Electroencephalography Study in Healthy Volunteers. Front Hum Neurosci 2017
Mashour et al, Bottom-Up and Top-Down Mechanisms of General Anesthetics Modulate Different Dimensions of Consciousness. Front Neural Circuits 2017
Pal et al, Propofol, Sevoflurane, and Ketamine Induce a Reversible Increase in Delta-Gamma and Theta-Gamma Phase-Amplitude Coupling in Frontal Cortex of Rat. Front Syst Neuroscience 2017
Maier et al, Protocol for the Reconstructing Consciousness and Cognition (ReCCognition) Study. Front Hum Neuroscience 2017
Liu X et al, Fine-grained parcellation of brain connectivity improves differentiation of states of consciousness during graded propofol sedation. Brain Connect 2017
Vlisides PE et al, Neuropohysiologic correlates of ketamine sedation and anesthesia : A high density electroencephalography study in healthy volunteers, Anesthesiology 2017
Li D et al, Accelerated recovery of consciousness after general anesthesia is associated with increased functional brain connectivity in the human gamma bandwidth, Front Syst Neurosci 2017
Hambrecht-Wiedbusch VS et al, Administration of subanesthetic ketamine during isoflurane anesthesia induces burst suppression but accelerates recovery. Anesthesiology 2017