2018 – Dr. Kamran Diba was awarded a multi-PI R01 grant, with co-PI Dr. Edwin (Ted) Abel at the University of Iowa, from NIMH.
This is a collaborative effort to investigate the “Molecular, cellular and circuit effects of sleep deprivation on hippocampal function” from multiple angles. A key part of this project will involve measurements and analyses in Dr. Diba’s lab of large-scale neuronal firing patterns in the hippocampus during memory acquisition and consolidation in waking and sleep, in rested and sleep-deprived animals. Dr. Kamran Diba was also awarded an R21 grant from the NIMH. In this work, Dr. Diba’s lab will use chemogenetic tools to manipulate cAMP protein signaling in hippocampal neurons in-vivo, in order to evaluate effects on hippocampal oscillations and memory.
2018- Dr. Anthony G. Hudetz, was awarded an R01 grant by the National Institute of General Medical Science of NIH to study the system-level neural mechanisms of anesthetic-induced unconsciousness.
Dr. Hudetz and his team will use functional magnetic resonance imaging to test the hypothesis that healthy human participants may be able to willfully engage in task-related mental imagery when sedated to the point of behavioral unresponsiveness and will seek to find a causal link between the state of intrinsic brain activity and volitional mental activity. The project will advance our understanding of the neuronal mechanisms of anesthesia with significant translational and paradigmatic impact for the clinical assessment of the state of consciousness and for the potential communication of patients via volitional mental activity.
2018- Dr. Phillip Vlisides, a core CCS faculty, was awarded an NIH Career Development Grant (K23) to study consciousness and cognition after surgery.
Dr. Vlisides and his team will analyze advanced neurophysiologic patterns-using electroencephalography and near-infrared spectroscopy-to better understand and predict cognitive impairment after surgery.
2018- Congratulations to Michael Brito (a second-year PhD candidate in Neuroscience working under Drs. George Mashour and Dinesh Pal) who has been awarded an National Science Foundation graduate research fellowship to study consciousness for his doctoral dissertation
2017- Dr. Dinesh Pal, CCS faculty and Assistant Professor of Anesthesiology, has been awarded a new R01 from the National Institutes of Health to study the mechanistic underpinnings of the interactions between sleep homeostasis and sedation
Dr. Pal will employ sophisticated techniques including high-density EEG in rodents and multi-neuroanalyte monitoring using mass spectrometry to answer a fundamental question: if and how sedatives can provide a sleep-like state. CCS director, Dr. Mashour is a co-investigator on the grant.
2017- CCS faculty receive new NIH funding to study the role of the hypothalamus in level of consciousness
Dr. Giancarlo Vanini will work with his co-PI, George Mashour, and other faculty in the Center for Consciousness Science to understand how sleep-promoting regions in the hypothalamus regulate the entry into and exit from the anesthetized state. Using cutting-edge chemogenetic techniques, they will also explore how these subcortical nuclei alter cortical connectivity and dynamics.
2016- CCS faculty receive NIH grant to study cortical connectivity in computational models, non-human primates, and surgical patients
CCS Directors Mashour and Lee have just been awarded a NIH R01 to conduct computational, neurobiological, and clinical studies of consciousness and anesthesia. CCS faculty Cindy Chestek (biomedical engineering) and Parag Patil (neurosurgery) are co-investigators.
2015- CCS receives grants from the National Institutes of Health and the James S. McDonnell Foundation to study brain networks as consciousness is lost and reconstituted
Dr. George Mashour and the CCS have been awarded major grants from the NIH and the prestigious James S. McDonnell Foundation to study consciousness in humans and nonhuman primates. The new NIH R01 will fund studies of healthy volunteers receiving ketamine and nitrous oxide; parallel studies examining cortical information transfer in the monkey brain during anesthetic state transitions will also be conducted. The McDonnell Foundation grant funds a translational neuroscience project conducted across multiple U.S. and Australian centers, led by the Center for Consciousness Science at the University of Michigan. The goal of this project is to study how the brain reconstitutes consciousness and cognition after major perturbations such as general anesthesia or seizures. The multidisciplinary teams assembled for the studies span the fields of neuroscience, physics, computational science, biomedical engineering, pain neurobiology, anesthesiology, neurosurgery, and psychiatry.
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