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Drs. George Mashour and Dinesh Pal were recently awarded an NIH R01 to study the role of the prefrontal cortex in arousal states

These studies will yield fundamental mechanistic knowledge of the neural pathways involved in arousal and recovery of consciousness, and will be of translational relevance across numerous fields.

Dr. Kamran Diba was awarded a multi-PI R01 grant, with co-PI Dr. Edwin (Ted) Abel at the University of Iowa, from NIMH.

This is a collaborative effort to investigate the “Molecular, cellular and circuit effects of sleep deprivation on hippocampal function” from multiple angles. A key part of this project will involve measurements and analyses in Dr. Diba’s lab of large-scale neuronal firing patterns in the hippocampus during memory acquisition and consolidation in waking and sleep, in rested and sleep-deprived animals. Dr. Kamran Diba was also awarded an R21 grant from the NIMH. In this work, Dr. Diba’s lab will use chemogenetic tools to manipulate cAMP protein signaling in hippocampal neurons in-vivo, in order to evaluate effects on hippocampal oscillations and memory.

Dr. Anthony G. Hudetz, was awarded an R01 grant by the National Institute of General Medical Science of NIH to study the system-level neural mechanisms of anesthetic-induced unconsciousness.

Dr. Hudetz and his team will use functional magnetic resonance imaging to test the hypothesis that healthy human participants may be able to willfully engage in task-related mental imagery when sedated to the point of behavioral unresponsiveness and will seek to find a causal link between the state of intrinsic brain activity and volitional mental activity. The project will advance our understanding of the neuronal mechanisms of anesthesia with significant translational and paradigmatic impact for the clinical assessment of the state of consciousness and for the potential communication of patients via volitional mental activity.

Recent publications by CCS faculty
Huang, Z et al, “Asymmetric neural dynamics characterize loss and recovery of consciousness". Neuroimage 2021
Huels, E et al, “Neural Correlates of the Shamanic State of Consciousness". Front Neurosci 2021
Parkar, A et al, “Carbachol and nicotine in prefrontal cortex have differential effects on sleep-wake states". Front Neurosci 2020
Mawla, I et al, “Greater somatosensory afference with acupuncture increases primary somatosensory connectivity and alleviates fibromyalgia pain via insular GABA: A randomized neuroimaging trial". Arthritis Rheumatol 2020
Lee, H et al, “Differential effect of anesthesia on visual cortex neurons with diverse population coupling". Neuroscience 2020
Larkin, T et al, “Altered network architecture of functional brain communities in chronic nociplastic pain". Neuroimage 2020
Mahdid, Y et al, “Assessing the quality of wearable EEG systems using functional connectivity". IEEE Access 2020
Zilio, F et al, “Are intrinsic neuronal timescales related to sensory processing? Evidence from abnormal behavioral states". Neuroimage 2020
Lee, H et al, “State-Dependent Cortical Unit Activity Reflects Dynamic Brain State Transitions in Anesthesia". J Neurosci 2020
Vlisides, P et al, “Deep Anaesthesia". Lancet 2020
Kallionpää, R et al, “Alpha band frontal connectivity is a state-specific electroencephalographic correlate of unresponsiveness during exposure to dexmedetomidine and propofol". Br J Anaesth 2020
Brito, M et al, "State-Dependent and Bandwidth-Specific Effects of Ketamine and Propofol on Electroencephalographic Complexity in Rats". Front Syst Neurosci 2020
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