Current News

Center for Consciousness Science Celebrates its 5-Year Anniversary!

CCS was founded 2014 to advance research, education, and clinical care related to consciousness.
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Jon Dean and Dr. Jimo Borjigin identify endogenous DMT, a psychedelic, in normal brain.

For more information, see: https://labblog.uofmhealth.org/lab-report/mystical-psychedelic-compound-found-normal-brains
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Dr. Mashour has published a new book entitled “Oxford Textbook of Neuroscience and Anaesthesiology” with Kristin Engelhard.

The text book covers neuroscientific basis of anesthesiology, the full spectrum of clinical neuroanaesthesia, and the care of neurologic patients...
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Research

2017- CCS faculty receive new NIH funding to study the role of the hypothalamus in level of consciousness

Dr. Giancarlo Vanini will work with his co-PI, George Mashour, and other faculty in the Center for Consciousness Science to understand how sleep-promoting regions in the hypothalamus regulate the entry into and exit from the anesthetized state. Using cutting-edge chemogenetic techniques, they will also explore how these subcortical nuclei alter cortical connectivity and dynamics.

2016- CCS faculty receive NIH grant to study cortical connectivity in computational models, non-human primates, and surgical patients

CCS Directors Mashour and Lee have just been awarded a NIH R01 to conduct computational, neurobiological, and clinical studies of consciousness and anesthesia. CCS faculty Cindy Chestek (biomedical engineering) and Parag Patil (neurosurgery) are co-investigators.

2015- CCS receives grants from the National Institutes of Health and the James S. McDonnell Foundation to study brain networks as consciousness is lost and reconstituted

Dr. George Mashour and the CCS have been awarded major grants from the NIH and the prestigious James S. McDonnell Foundation to study consciousness in humans and nonhuman primates. The new NIH R01 will fund studies of healthy volunteers receiving ketamine and nitrous oxide; parallel studies examining cortical information transfer in the monkey brain during anesthetic state transitions will also be conducted. The McDonnell Foundation grant funds a translational neuroscience project conducted across multiple U.S. and Australian centers, led by the Center for Consciousness Science at the University of Michigan. The goal of this project is to study how the brain reconstitutes consciousness and cognition after major perturbations such as general anesthesia or seizures. The multidisciplinary teams assembled for the studies span the fields of neuroscience, physics, computational science, biomedical engineering, pain neurobiology, anesthesiology, neurosurgery, and psychiatry.

Recent publications by CCS faculty
Huang, Z et al, “Asymmetric neural dynamics characterize loss and recovery of consciousness". Neuroimage 2021
Huels, E et al, “Neural Correlates of the Shamanic State of Consciousness". Front Neurosci 2021
Parkar, A et al, “Carbachol and nicotine in prefrontal cortex have differential effects on sleep-wake states". Front Neurosci 2020
Mawla, I et al, “Greater somatosensory afference with acupuncture increases primary somatosensory connectivity and alleviates fibromyalgia pain via insular GABA: A randomized neuroimaging trial". Arthritis Rheumatol 2020
Lee, H et al, “Differential effect of anesthesia on visual cortex neurons with diverse population coupling". Neuroscience 2020
Larkin, T et al, “Altered network architecture of functional brain communities in chronic nociplastic pain". Neuroimage 2020
Mahdid, Y et al, “Assessing the quality of wearable EEG systems using functional connectivity". IEEE Access 2020
Zilio, F et al, “Are intrinsic neuronal timescales related to sensory processing? Evidence from abnormal behavioral states". Neuroimage 2020
Lee, H et al, “State-Dependent Cortical Unit Activity Reflects Dynamic Brain State Transitions in Anesthesia". J Neurosci 2020
Vlisides, P et al, “Deep Anaesthesia". Lancet 2020
Kallionpää, R et al, “Alpha band frontal connectivity is a state-specific electroencephalographic correlate of unresponsiveness during exposure to dexmedetomidine and propofol". Br J Anaesth 2020
Brito, M et al, "State-Dependent and Bandwidth-Specific Effects of Ketamine and Propofol on Electroencephalographic Complexity in Rats". Front Syst Neurosci 2020
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