Dr. George Mashour and the CCS have been awarded major grants from the NIH and the prestigious James S. McDonnell Foundation to study consciousness in humans and nonhuman primates. The new NIH R01 will fund studies of healthy volunteers receiving ketamine and nitrous oxide; parallel studies examining cortical information transfer in the monkey brain during anesthetic state transitions will also be conducted. The McDonnell Foundation grant funds a translational neuroscience project conducted across multiple U.S. and Australian centers, led by the Center for Consciousness Science at the University of Michigan. The goal of this project is to study how the brain reconstitutes consciousness and cognition after major perturbations such as general anesthesia or seizures. The multidisciplinary teams assembled for the studies span the fields of neuroscience, physics, computational science, biomedical engineering, pain neurobiology, anesthesiology, neurosurgery, and psychiatry.