Dr. Hudetz and his team will use functional magnetic resonance imaging to test the hypothesis that healthy human participants may be able to willfully engage in task-related mental imagery when sedated to the point of behavioral unresponsiveness and will seek to find a causal link between the state of intrinsic brain activity and volitional mental activity. The project will advance our understanding of the neuronal mechanisms of anesthesia with significant translational and paradigmatic impact for the clinical assessment of the state of consciousness and for the potential communication of patients via volitional mental activity.