Research

The Center for Consciousness Science (CCS) conducts studies across the translational spectrum, from computational brain models, to experiments in animals, to studies of healthy humans, to clinical trials in patients.

Furthermore, our basic science research program includes neural circuit manipulation through pharmacological, electrical stimulation, chemogenetic, and optogenetic techniques. The CCS has deep expertise in analyses involving graph theory, advanced functional connectivity measures, and neural dynamics. We are fortunate to have robust support from the National Institutes of Health and have had major grants from the James S. McDonnell Foundation.

Latest Research News

CCS Scientific Director George Mashour publishes new paper in eLife that examines how the brain recovers from unconsciousness after anesthesia

Understanding how the brain recovers from unconsciousness can inform neurobiological theories of consciousness and guide clinical investigation.
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CCS faculty publish article in Cell Reports on the gate of consciousness

Conscious access to sensory information is likely gated at an intermediate site between primary sensory and transmodal association cortices, but the structure responsible remains unknown.
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Four-year 1.4M grant award by NIH/NIGMS to PI Dr. Tony Hudetz to continue studying the neural mechanism by which general anesthetics modulate consciousness.

The overall goal of this research project is to investigate local neuronal mechanisms in the cerebral cortex associated with complex,...
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Drs. George Mashour and Dinesh Pal were recently awarded an NIH R01 to study the role of the prefrontal cortex in arousal states

These studies will yield fundamental mechanistic knowledge of the neural pathways involved in arousal and recovery of consciousness, and will...
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Recent Publications

Parkar, A et al, “Carbachol and nicotine in prefrontal cortex have differential effects on sleep-wake states”. Front Neurosci 2020

Mawla, I et al, “Greater somatosensory afference with acupuncture increases primary somatosensory connectivity and alleviates fibromyalgia pain via insular GABA: A randomized neuroimaging trial”. Arthritis Rheumatol 2020

Lee, H et al, “Differential effect of anesthesia on visual cortex neurons with diverse population coupling”. Neuroscience 2020

Larkin, T et al, “Altered network architecture of functional brain communities in chronic nociplastic pain”. Neuroimage 2020

Mahdid, Y et al, “Assessing the quality of wearable EEG systems using functional connectivity”. IEEE Access 2020

Zilio, F et al, “Are intrinsic neuronal timescales related to sensory processing? Evidence from abnormal behavioral states”. Neuroimage 2020

Lee, H et al, “State-Dependent Cortical Unit Activity Reflects Dynamic Brain State Transitions in Anesthesia”. J Neurosci 2020

Vlisides, P et al, “Deep Anaesthesia”. Lancet 2020

Kallionpää, R et al, “Alpha band frontal connectivity is a state-specific electroencephalographic correlate of unresponsiveness during exposure to dexmedetomidine and propofol”. Br J Anaesth 2020

Brito, M et al, “State-Dependent and Bandwidth-Specific Effects of Ketamine and Propofol on Electroencephalographic Complexity in Rats”. Front Syst Neurosci 2020

Huang, Z et al, “Rest-task modulation of fMRI-derived global signal topography is mediated by transient coactivation patterns”. PLoS Biology 2020

Tanabe, S et al, “Altered Global Brain Signal during Physiologic, Pharmacologic, and Pathologic States of Unconsciousness in Humans and Rats”. Anesthesiology 2020

Huang, Z et al, “Temporal circuit of macroscale dynamic brain activity supports human consciousness”. Science Advances 2020

Mashour GA et al, “Conscious Processing and the Global Neuronal Workspace Hypothesis”. Neuron 2020

Hudetz AG et al, “Desflurane Anesthesia Alters Cortical Layer-specific Hierarchical Interactions in Rat Cerebral Cortex”. Anesthesiology 2020

Campbell JM et al, “Pharmacologically informed machine learning approach for identifying pathological states of unconsciousness via resting-state fMRI”. Neuroimage 2020

Vanini G et al, “Activation of Preoptic GABAergic or Glutamatergic Neurons Modulates Sleep-Wake Architecture, but Not Anesthetic State Transitions”. Curr Biol. 2020

Li D et al, “Age-Related Changes in Cortical Connectivity During Surgical Anesthesia” Front Aging Neuroscience 2020

Pal D et al, “Level of Consciousness Is Dissociable from Electroencephalographic Measures of Cortical Connectivity, Slow Oscillations, and Complexity”. J Neurosci. 2020